As part of a global transformation effort, Sanofi has launched its Manufacturing System 2.0 initiative—placing maintenance and reliability at the heart of operational performance. At the core lies a harmonized, worldwide ecosystem: a structured asset management program integrating standardized operating procedures, unified ways of working, and embedded reliability engineering practices. This session will provide insights into how Sanofi is building a scalable and sustainable maintenance model across its global sites. From defining clear operating standards to embedding reliability from design through execution, this approach is driving consistency, performance, and long-term equipment health.