• Who has implemented an MES?

Over or under 5 years?

• What is the baseline requirement for being able to call your operations digitally mature?
• How does it fit into concepts and applications such as Cloud/Edge, IIoT, Big Data, AI/ML, AR/VR, etc.?

Are there currently any practical improvements seen by AI/ML in your plants? Or if not, how do you see it’s applications in the future, how will it help you once you have the data?

• What effects on your plant’s digital maturity did you observe after the implementation of MES?

If it was a phased approach (e.g. eLogs > eBR > interfaces > pharma 4.0 technologies), which stage was the most difficult and which had the biggest payoff?

• How has introduction of an MES affected your processes flexibility?

For processes that require a high degree of flexibility, have you seen a reduction in flexibility with MES and have the benefits outweighed the loss? (e.g. clinical phase II or III).

Are the technology/quality systems ready for enabling flexible MES solutions for these product stages? What makes them so?